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Drug Design Data Resource Grand Challenge 3 Dataset: JAK2_SC3
Janus Kinase 2 (JAK2) is an intracellular protein tyrosine kinase that is critical to the mediation of cytokine signaling. Its dysregulation is involved in multiple diseases, including autoimmune diseases (rheumatoid arthritis and psoriasis), myeloproliferative syndromes (polycythemia vera, leukemias, and lymphomas), and cardiovascular diseases. This is an affinity ranking/scoring, and free energy challenge, designed to test the ability of current methods to detect large changes in affinity due to small changes in chemical structure. The dataset comprises 17 congeneric compounds with Kd values for the kinase JAK2. Note that the chiral compounds were measured as racemates.
Data Files
| File Name | Description | Date Added | Download |
|---|---|---|---|
| GC3_JAK2_SC3.zip | JAK2_SC3 Dataset from Grand Challenge 3 | 03:45pm February 6, 2020 | Download |
Document Files
| File Name | Description | Date Added | Download |
|---|---|---|---|
| No Document Files |
About
Welcome to the Drug Design Data Resource Community. D3R is funded in part by NIH grant 1U01GM111528 from the National Institute of General Medical Sciences
